Thiothixene and chromium?

Q: Dear Doctor, My sister is taking 500 mg of Depakote per day and 4-6 mg of Thiothixene during her psychotic episodes. Recently we started her on 400 mcg of chromium per day. Is that alright?

A: I wish I could be definite, but in truth I don't know the answer to your question. If I were prescribing thiothixene to a patient,I would warn them that thiothixene can precipitate seizures,especially in people with a history of seizures or who are withdrawing from alcohol. I wonder if the addition of chromium might increase the liklihood of a seizure, but again I don't know. Please consult, or suggest that your sister consult, her psychiatrist. Please let me know if chromium helps her. Thank you.
Dr. McLeod